Bicalutamide: Uses, Dosage, Side Effects & Safety Guide

If you or someone you know has been prescribed Bicalutamide, you probably have a lot of questions. Below you’ll find the essentials you need to know—what the drug does, how to use it, what side effects to expect, and how to stay safe while taking it.

How Bicalutamide Works

Bicalutamide belongs to a class of medicines called anti‑androgens. It blocks the action of male hormones (androgens) that can fuel the growth of prostate cancer cells. By tying up the hormone receptors, the drug helps slow down tumor growth and can improve the effectiveness of other hormone therapies.

Who Should Take Bicalutamide

The drug is most commonly prescribed for men with advanced prostate cancer that has spread beyond the prostate gland. It’s also used after surgery or radiation to keep the cancer from coming back. Your doctor will decide if Bicalutamide fits your treatment plan based on your PSA levels, imaging results, and overall health.

Typical dosage

Adults usually take one 50 mg tablet once a day, with or without food. Some doctors may start you on a lower dose if you have liver problems or are taking other medications that affect the liver. Never change the dose on your own—always follow your prescriber’s instructions.

How to take it safely

Swallow the tablet whole; don’t chew or crush it. If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose—then skip the missed one. Taking two tablets at once can increase side effects, so stick to the schedule.

Common side effects

• Hot flashes or sweating
• Breast tenderness or enlargement
• Nausea or mild stomach upset
• Fatigue
• Changes in liver blood tests

Most of these are mild and go away after a few weeks. If you notice a sudden rash, severe stomach pain, yellowing of the skin or eyes, or dark urine, call your doctor right away—these could be signs of a liver issue.

Things to watch for

Bicalutamide can affect hormone levels, so you might feel less interested in sex or notice changes in mood. Talk to your doctor if these symptoms bother you; they might adjust the dose or add another medication to help.

Drug interactions

Because Bicalutamide is processed by the liver, drugs that also use liver enzymes (like certain antifungals, antibiotics, or seizure meds) can raise or lower its levels. Always share your full medication list with your healthcare team, including over‑the‑counter pills and herbal supplements.

Pregnancy and breastfeeding

The drug can cause birth defects, so women who are pregnant, might become pregnant, or are breastfeeding should avoid handling the tablets. If you’re a caregiver, wear gloves when handling the medication.

Monitoring and follow‑up

Your doctor will order blood tests regularly to check liver function and PSA levels. These appointments help catch problems early and let the doctor see if the treatment is working.

In short, Bicalutamide can be a powerful tool against prostate cancer when used correctly. Stick to the prescribed dose, report any unusual symptoms, and keep up with lab tests. With the right care, you can manage the disease while minimizing side effects.